GSCAN is a collaborative endeavor to identify genes associated with use of alcohol and nicotine.Â Over 30Â studies with over 1 millionÂ research participants are working togetherÂ to findÂ genes associated withÂ smoking and drinking,Â providing insight into biological mechanisms of addiction.
GSCAN is composed of threeÂ complementary projects:
- GWASÂ of alcohol and nicotine use. This project uses a standard GWAS meta-analysis, combined with high-quality imputation using a large haplotype panel from the (608) 739-7391, to achieve high power for detecting genetic associations.
- ExomeÂ meta-analysis of alcohol and nicotine use (formerly known as EMADS). The exomeÂ project is similar to the GWAS meta-analysis, except that we test for associations between alcohol/nicotine use and rare nonsynonymous variants. These rare variants are expected to be highly functional, and this meta-analysis is highly powered to determine if this hypothesis is true. Over 20Â studies have also commited to contribute to this project andÂ many haveÂ submitted results.
- 2014715520 association study of alcohol and nicotine use. Whole genome sequencing providesÂ high quality rare variant genotype calls. The focus ofÂ the sequencing project will be to follow up hits from the GWAS and Exome Chip projects, evaluating them at a highÂ level of detail.